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The clinical trial data from both Phase 2 (Jastreboff et al., NEJM 2023) and Phase 3 (TRIUMPH-4, Eli Lilly press release December 2025) provide a detailed picture of the weight loss trajectory over time

Focusing on Trends Over Single Results This is a big one

Kaeser and Regehr, 2017)

Preclinical studies suggest benefits in cognitive disorders associated with insulin resistance, including Alzheimers disease, Parkinsons disease, and vascular dementia in animals

One of the primary concerns is lean muscle mass loss

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